Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application

Tulay Irez; Onur Güralp; Hakan Yelke; Semra Kahraman

doi:doi:10.11648/j.abb.20210903.14

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Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application

Tulay Irez, Onur Güralp, Hakan Yelke, Semra Kahraman

Published in Advances in Bioscience and Bioengineering (Volume 9, Issue 3)

Received: 7 August 2021 Accepted: 20 August 2021 Published: 10 September 2021

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Abstract

Aim: Failed fertilization (FF) occurs in approximately 2–3% of ICSI cycles and is mainly due to lack of oocyte activation. The reasons of total fertilization insufficiency in ICSI applications can be listed as mitosis errors, sperm aster formation defects, sperm decondensation defects, PN formation defects and oocyte activation defects. In this study, sperm functions, oocyte morphology, hormone levels and possible effects of gonadotropins used in the treatment were investigated retrospectively. Material and Methods: In this study, semen parameters and sperm functions, oocyte morphology, basal hormone values and treatment processes of 32 fertilization failure cases and 91 fertile controls were compared. Results: It was found that age of female and male, basal FSH value and gonadotropin used in the treatment process were higher in total fertilization failure cases compared to fertile controls (p = 0.004, p = 0.041, p = 0.008, p = 0.004). Basal AMH level, total oocyte count, M2 oocyte count, quality oocyte count and normal ZP percentage were lower in fertilization failure cases (p = 0.002, p = 0.000, p = 0.000, p = 0.008, p = 0.000). There was no statistically significant difference between the two groups in terms of sperm functions. Conclusions: It was understood that high FSH and low AMH levels and high-dose gonadotropin treatment in cases with optimal sperm quality may cause oocyte cytoplasmic and zona pellucida abnormalities, and it should be discussed as a cause of fertilization failure.

Published in	Advances in Bioscience and Bioengineering (Volume 9, Issue 3)
DOI	10.11648/j.abb.20210903.14
Page(s)	87-91
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antimullerian Hormone, Oocyte Abnormalities, Fertilization Failure

References

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APA Style

Tulay Irez, Onur Güralp, Hakan Yelke, Semra Kahraman. (2021). Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application. Advances in Bioscience and Bioengineering, 9(3), 87-91. https://doi.org/10.11648/j.abb.20210903.14

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ACS Style

Tulay Irez; Onur Güralp; Hakan Yelke; Semra Kahraman. Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application. Adv. BioSci. Bioeng. 2021, 9(3), 87-91. doi: 10.11648/j.abb.20210903.14

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AMA Style

Tulay Irez, Onur Güralp, Hakan Yelke, Semra Kahraman. Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application. Adv BioSci Bioeng. 2021;9(3):87-91. doi: 10.11648/j.abb.20210903.14

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@article{10.11648/j.abb.20210903.14,
  author = {Tulay Irez and Onur Güralp and Hakan Yelke and Semra Kahraman},
  title = {Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application},
  journal = {Advances in Bioscience and Bioengineering},
  volume = {9},
  number = {3},
  pages = {87-91},
  doi = {10.11648/j.abb.20210903.14},
  url = {https://doi.org/10.11648/j.abb.20210903.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20210903.14},
  abstract = {Aim: Failed fertilization (FF) occurs in approximately 2–3% of ICSI cycles and is mainly due to lack of oocyte activation. The reasons of total fertilization insufficiency in ICSI applications can be listed as mitosis errors, sperm aster formation defects, sperm decondensation defects, PN formation defects and oocyte activation defects. In this study, sperm functions, oocyte morphology, hormone levels and possible effects of gonadotropins used in the treatment were investigated retrospectively. Material and Methods: In this study, semen parameters and sperm functions, oocyte morphology, basal hormone values and treatment processes of 32 fertilization failure cases and 91 fertile controls were compared. Results: It was found that age of female and male, basal FSH value and gonadotropin used in the treatment process were higher in total fertilization failure cases compared to fertile controls (p = 0.004, p = 0.041, p = 0.008, p = 0.004). Basal AMH level, total oocyte count, M2 oocyte count, quality oocyte count and normal ZP percentage were lower in fertilization failure cases (p = 0.002, p = 0.000, p = 0.000, p = 0.008, p = 0.000). There was no statistically significant difference between the two groups in terms of sperm functions. Conclusions: It was understood that high FSH and low AMH levels and high-dose gonadotropin treatment in cases with optimal sperm quality may cause oocyte cytoplasmic and zona pellucida abnormalities, and it should be discussed as a cause of fertilization failure.},
 year = {2021}
}

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TY  - JOUR
T1  - Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application
AU  - Tulay Irez
AU  - Onur Güralp
AU  - Hakan Yelke
AU  - Semra Kahraman
Y1  - 2021/09/10
PY  - 2021
N1  - https://doi.org/10.11648/j.abb.20210903.14
DO  - 10.11648/j.abb.20210903.14
T2  - Advances in Bioscience and Bioengineering
JF  - Advances in Bioscience and Bioengineering
JO  - Advances in Bioscience and Bioengineering
SP  - 87
EP  - 91
PB  - Science Publishing Group
SN  - 2330-4162
UR  - https://doi.org/10.11648/j.abb.20210903.14
AB  - Aim: Failed fertilization (FF) occurs in approximately 2–3% of ICSI cycles and is mainly due to lack of oocyte activation. The reasons of total fertilization insufficiency in ICSI applications can be listed as mitosis errors, sperm aster formation defects, sperm decondensation defects, PN formation defects and oocyte activation defects. In this study, sperm functions, oocyte morphology, hormone levels and possible effects of gonadotropins used in the treatment were investigated retrospectively. Material and Methods: In this study, semen parameters and sperm functions, oocyte morphology, basal hormone values and treatment processes of 32 fertilization failure cases and 91 fertile controls were compared. Results: It was found that age of female and male, basal FSH value and gonadotropin used in the treatment process were higher in total fertilization failure cases compared to fertile controls (p = 0.004, p = 0.041, p = 0.008, p = 0.004). Basal AMH level, total oocyte count, M2 oocyte count, quality oocyte count and normal ZP percentage were lower in fertilization failure cases (p = 0.002, p = 0.000, p = 0.000, p = 0.008, p = 0.000). There was no statistically significant difference between the two groups in terms of sperm functions. Conclusions: It was understood that high FSH and low AMH levels and high-dose gonadotropin treatment in cases with optimal sperm quality may cause oocyte cytoplasmic and zona pellucida abnormalities, and it should be discussed as a cause of fertilization failure.
VL  - 9
IS  - 3
ER  -

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Author Information

Tulay Irez

Department of Histology and Embryology, Medical Faculty, Istanbul Yeni Yuzyil University, Istanbul, Turkey
Onur Güralp

Department of Gynaecology& Obstetrics, Medical Faculty, University of Oldenburg, Oldenburg, Germany
Hakan Yelke

Department of IVF and Gynetics Center, Sisli Memorial Hospital, Istanbul, Turkey
Semra Kahraman

Department of Gynecology and Obstetrics and IVF and Gynetics Center, Sisli Memorial Hospital, Istanbul, Turkey

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APA Style

Tulay Irez, Onur Güralp, Hakan Yelke, Semra Kahraman. (2021). Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application. Advances in Bioscience and Bioengineering, 9(3), 87-91. https://doi.org/10.11648/j.abb.20210903.14

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ACS Style

Tulay Irez; Onur Güralp; Hakan Yelke; Semra Kahraman. Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application. Adv. BioSci. Bioeng. 2021, 9(3), 87-91. doi: 10.11648/j.abb.20210903.14

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AMA Style

Tulay Irez, Onur Güralp, Hakan Yelke, Semra Kahraman. Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application. Adv BioSci Bioeng. 2021;9(3):87-91. doi: 10.11648/j.abb.20210903.14

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@article{10.11648/j.abb.20210903.14,
  author = {Tulay Irez and Onur Güralp and Hakan Yelke and Semra Kahraman},
  title = {Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application},
  journal = {Advances in Bioscience and Bioengineering},
  volume = {9},
  number = {3},
  pages = {87-91},
  doi = {10.11648/j.abb.20210903.14},
  url = {https://doi.org/10.11648/j.abb.20210903.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20210903.14},
  abstract = {Aim: Failed fertilization (FF) occurs in approximately 2–3% of ICSI cycles and is mainly due to lack of oocyte activation. The reasons of total fertilization insufficiency in ICSI applications can be listed as mitosis errors, sperm aster formation defects, sperm decondensation defects, PN formation defects and oocyte activation defects. In this study, sperm functions, oocyte morphology, hormone levels and possible effects of gonadotropins used in the treatment were investigated retrospectively. Material and Methods: In this study, semen parameters and sperm functions, oocyte morphology, basal hormone values and treatment processes of 32 fertilization failure cases and 91 fertile controls were compared. Results: It was found that age of female and male, basal FSH value and gonadotropin used in the treatment process were higher in total fertilization failure cases compared to fertile controls (p = 0.004, p = 0.041, p = 0.008, p = 0.004). Basal AMH level, total oocyte count, M2 oocyte count, quality oocyte count and normal ZP percentage were lower in fertilization failure cases (p = 0.002, p = 0.000, p = 0.000, p = 0.008, p = 0.000). There was no statistically significant difference between the two groups in terms of sperm functions. Conclusions: It was understood that high FSH and low AMH levels and high-dose gonadotropin treatment in cases with optimal sperm quality may cause oocyte cytoplasmic and zona pellucida abnormalities, and it should be discussed as a cause of fertilization failure.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Could Antimullerian Hormone Play a Role in Fertilization Failure in ICSI Application
AU  - Tulay Irez
AU  - Onur Güralp
AU  - Hakan Yelke
AU  - Semra Kahraman
Y1  - 2021/09/10
PY  - 2021
N1  - https://doi.org/10.11648/j.abb.20210903.14
DO  - 10.11648/j.abb.20210903.14
T2  - Advances in Bioscience and Bioengineering
JF  - Advances in Bioscience and Bioengineering
JO  - Advances in Bioscience and Bioengineering
SP  - 87
EP  - 91
PB  - Science Publishing Group
SN  - 2330-4162
UR  - https://doi.org/10.11648/j.abb.20210903.14
AB  - Aim: Failed fertilization (FF) occurs in approximately 2–3% of ICSI cycles and is mainly due to lack of oocyte activation. The reasons of total fertilization insufficiency in ICSI applications can be listed as mitosis errors, sperm aster formation defects, sperm decondensation defects, PN formation defects and oocyte activation defects. In this study, sperm functions, oocyte morphology, hormone levels and possible effects of gonadotropins used in the treatment were investigated retrospectively. Material and Methods: In this study, semen parameters and sperm functions, oocyte morphology, basal hormone values and treatment processes of 32 fertilization failure cases and 91 fertile controls were compared. Results: It was found that age of female and male, basal FSH value and gonadotropin used in the treatment process were higher in total fertilization failure cases compared to fertile controls (p = 0.004, p = 0.041, p = 0.008, p = 0.004). Basal AMH level, total oocyte count, M2 oocyte count, quality oocyte count and normal ZP percentage were lower in fertilization failure cases (p = 0.002, p = 0.000, p = 0.000, p = 0.008, p = 0.000). There was no statistically significant difference between the two groups in terms of sperm functions. Conclusions: It was understood that high FSH and low AMH levels and high-dose gonadotropin treatment in cases with optimal sperm quality may cause oocyte cytoplasmic and zona pellucida abnormalities, and it should be discussed as a cause of fertilization failure.
VL  - 9
IS  - 3
ER  -

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