Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease

Chengsheng Liu; Jiehua Xie

doi:doi:10.11648/j.abb.20200804.13

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Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease

Chengsheng Liu, Jiehua Xie

Published in Advances in Bioscience and Bioengineering (Volume 8, Issue 4)

Received: 6 December 2020 Accepted: 16 December 2020 Published: 22 December 2020

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Abstract

Backgroud: Nonalcoholic fatty liver disease has become the second largest source of chronic liver disease in the urban population. Metformin, a traditional drug, has good prospects for treating the disease in primary health care facilities. Objective: To summarize and grasp the status of metformin in adults, children with diabetes and non-diabetic NAFLD patients. Methods: We reviewed 31 relevant research literatures in PubMed database, and sorted out some preclinical and clinical research results. Results: Metformin was found to have a good effect in improving liver function indicators in both adult diabetic and non-diabetic NAFLD patients, and could benefit liver histology in NAFLD patients with adult diabetes. Metformin treatment did not show a significant advantage over lifestyle interventions in children with NAFLD. Conclusion: Metformin can improve the liver function and histological structure of adult NAFLD patients to a certain extent, and children patients should still be treated mainly with improved lifestyle.

Published in	Advances in Bioscience and Bioengineering (Volume 8, Issue 4)
DOI	10.11648/j.abb.20200804.13
Page(s)	78-81
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Non-alcoholic Fatty Liver Disease, Metformin, Diabetes

References

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APA Style

Chengsheng Liu, Jiehua Xie. (2020). Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease. Advances in Bioscience and Bioengineering, 8(4), 78-81. https://doi.org/10.11648/j.abb.20200804.13

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ACS Style

Chengsheng Liu; Jiehua Xie. Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease. Adv. BioSci. Bioeng. 2020, 8(4), 78-81. doi: 10.11648/j.abb.20200804.13

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AMA Style

Chengsheng Liu, Jiehua Xie. Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease. Adv BioSci Bioeng. 2020;8(4):78-81. doi: 10.11648/j.abb.20200804.13

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@article{10.11648/j.abb.20200804.13,
  author = {Chengsheng Liu and Jiehua Xie},
  title = {Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease},
  journal = {Advances in Bioscience and Bioengineering},
  volume = {8},
  number = {4},
  pages = {78-81},
  doi = {10.11648/j.abb.20200804.13},
  url = {https://doi.org/10.11648/j.abb.20200804.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20200804.13},
  abstract = {Backgroud: Nonalcoholic fatty liver disease has become the second largest source of chronic liver disease in the urban population. Metformin, a traditional drug, has good prospects for treating the disease in primary health care facilities. Objective: To summarize and grasp the status of metformin in adults, children with diabetes and non-diabetic NAFLD patients. Methods: We reviewed 31 relevant research literatures in PubMed database, and sorted out some preclinical and clinical research results. Results: Metformin was found to have a good effect in improving liver function indicators in both adult diabetic and non-diabetic NAFLD patients, and could benefit liver histology in NAFLD patients with adult diabetes. Metformin treatment did not show a significant advantage over lifestyle interventions in children with NAFLD. Conclusion: Metformin can improve the liver function and histological structure of adult NAFLD patients to a certain extent, and children patients should still be treated mainly with improved lifestyle.},
 year = {2020}
}

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TY  - JOUR
T1  - Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease
AU  - Chengsheng Liu
AU  - Jiehua Xie
Y1  - 2020/12/22
PY  - 2020
N1  - https://doi.org/10.11648/j.abb.20200804.13
DO  - 10.11648/j.abb.20200804.13
T2  - Advances in Bioscience and Bioengineering
JF  - Advances in Bioscience and Bioengineering
JO  - Advances in Bioscience and Bioengineering
SP  - 78
EP  - 81
PB  - Science Publishing Group
SN  - 2330-4162
UR  - https://doi.org/10.11648/j.abb.20200804.13
AB  - Backgroud: Nonalcoholic fatty liver disease has become the second largest source of chronic liver disease in the urban population. Metformin, a traditional drug, has good prospects for treating the disease in primary health care facilities. Objective: To summarize and grasp the status of metformin in adults, children with diabetes and non-diabetic NAFLD patients. Methods: We reviewed 31 relevant research literatures in PubMed database, and sorted out some preclinical and clinical research results. Results: Metformin was found to have a good effect in improving liver function indicators in both adult diabetic and non-diabetic NAFLD patients, and could benefit liver histology in NAFLD patients with adult diabetes. Metformin treatment did not show a significant advantage over lifestyle interventions in children with NAFLD. Conclusion: Metformin can improve the liver function and histological structure of adult NAFLD patients to a certain extent, and children patients should still be treated mainly with improved lifestyle.
VL  - 8
IS  - 4
ER  -

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Author Information

Chengsheng Liu

Health Center of Huashan Town, Guangzhou, China
Jiehua Xie

District Center for Disease Control and Prevention, Guangzhou, China

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Plain Text BibTeX RIS

APA Style

Chengsheng Liu, Jiehua Xie. (2020). Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease. Advances in Bioscience and Bioengineering, 8(4), 78-81. https://doi.org/10.11648/j.abb.20200804.13

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ACS Style

Chengsheng Liu; Jiehua Xie. Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease. Adv. BioSci. Bioeng. 2020, 8(4), 78-81. doi: 10.11648/j.abb.20200804.13

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AMA Style

Chengsheng Liu, Jiehua Xie. Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease. Adv BioSci Bioeng. 2020;8(4):78-81. doi: 10.11648/j.abb.20200804.13

Copy | Download

@article{10.11648/j.abb.20200804.13,
  author = {Chengsheng Liu and Jiehua Xie},
  title = {Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease},
  journal = {Advances in Bioscience and Bioengineering},
  volume = {8},
  number = {4},
  pages = {78-81},
  doi = {10.11648/j.abb.20200804.13},
  url = {https://doi.org/10.11648/j.abb.20200804.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20200804.13},
  abstract = {Backgroud: Nonalcoholic fatty liver disease has become the second largest source of chronic liver disease in the urban population. Metformin, a traditional drug, has good prospects for treating the disease in primary health care facilities. Objective: To summarize and grasp the status of metformin in adults, children with diabetes and non-diabetic NAFLD patients. Methods: We reviewed 31 relevant research literatures in PubMed database, and sorted out some preclinical and clinical research results. Results: Metformin was found to have a good effect in improving liver function indicators in both adult diabetic and non-diabetic NAFLD patients, and could benefit liver histology in NAFLD patients with adult diabetes. Metformin treatment did not show a significant advantage over lifestyle interventions in children with NAFLD. Conclusion: Metformin can improve the liver function and histological structure of adult NAFLD patients to a certain extent, and children patients should still be treated mainly with improved lifestyle.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Research Progress of Metformin in the Treatment of Non-alcoholic Fatty Liver Disease
AU  - Chengsheng Liu
AU  - Jiehua Xie
Y1  - 2020/12/22
PY  - 2020
N1  - https://doi.org/10.11648/j.abb.20200804.13
DO  - 10.11648/j.abb.20200804.13
T2  - Advances in Bioscience and Bioengineering
JF  - Advances in Bioscience and Bioengineering
JO  - Advances in Bioscience and Bioengineering
SP  - 78
EP  - 81
PB  - Science Publishing Group
SN  - 2330-4162
UR  - https://doi.org/10.11648/j.abb.20200804.13
AB  - Backgroud: Nonalcoholic fatty liver disease has become the second largest source of chronic liver disease in the urban population. Metformin, a traditional drug, has good prospects for treating the disease in primary health care facilities. Objective: To summarize and grasp the status of metformin in adults, children with diabetes and non-diabetic NAFLD patients. Methods: We reviewed 31 relevant research literatures in PubMed database, and sorted out some preclinical and clinical research results. Results: Metformin was found to have a good effect in improving liver function indicators in both adult diabetic and non-diabetic NAFLD patients, and could benefit liver histology in NAFLD patients with adult diabetes. Metformin treatment did not show a significant advantage over lifestyle interventions in children with NAFLD. Conclusion: Metformin can improve the liver function and histological structure of adult NAFLD patients to a certain extent, and children patients should still be treated mainly with improved lifestyle.
VL  - 8
IS  - 4
ER  -

Copy | Download